摘要:Objective To investigate the plantar pressure distribution and gait changes in type 2 diabetic patients with peripheral neuropathy.Methods A total of 303 patients with type 2 diabetes hospitalized were enrolled and divided into diabetic peripheral neuropathy (DPN) group (n =137) or diabetic control (DC,without DPN) group (n =166).Demographic characteristics and related biochemical indexes were recorded.Parameters of Plantar pressure and gait were recorded with the FootScan system.Independent t-test or Mann Whaitney U test and Spearman rank correlation analysis were applied in the data analysis.Results Compared with DC group,plantar peak pressures in third metatarsal [(13.15 ± 4.22) N/cm2 vs.(11.96 ± 3.94) N/ema2,P < 0.05] or forth metatarsal [(10.21 ± 4.22) N/cm2 vs.(9.14 ± 3.66) N/cm2,P < 0.05] on the left foot and in the first [(6.02 ± 2.79) N/cm2 vs.(5.04 ± 2.87) N/cm2,P < 0.05],the second [(9.95 ±2.69) N/cm2 vs.(9.18 ±2.77) N/cm2,P <0.05],the third [(10.90 ±3.23) N/cm2 vs.(9.93 ± 3.09) N/cm2,P < 0.05] metatarsal on the right foot were significantly decreased.There was no significant difference in pressure-time intergrals in each region,total force,total force-time intergrals,or total contact area between the two groups (P >0.05).In comparison with those in DC group,foot flat phase extended [56.8% (50.22%-62.45%) vs.59.5% (54.25%-64.15%),P < 0.05],forefoot push off phase shorten [31.25% (25.475%-35.775%) vs.29% (24.95%-33.65%),P<0.05] in stance phase,and total contact time [(858 ± 12)ms vs.(900 ± 127)ms,P< 0.05] were increased significantly,while walking speed was significantly decreased [(2.58 ± 0.67) km/h vs.(2.28 ± 0.66)km/h,P <0.05] in DPN group.Walking speed and forefoot push off phase changes were positively correlated with peak pressure changes,while foot fiat phase changes was negative correlated with peak pressure.Conclusion In DPN patients,walking speed decreases,foot flat phase is extended,and forefoot push off phase is shorten in stance phase;however,peak pressure and pressure-time intergrals does not increase significantly.While evaluating plantar pressure in diabetic patients,walking speed and gait should be controlled and pressure-time intergral may be better reflecting the plantar loading.%目的 了解2型糖尿病合并周圍神經病變患者的足底壓力與步態變化.方法 納入住院的303例2型糖尿病患者,分為糖尿病無周圍神經病變組(DC組)和糖尿病周圍神經病變組(DPN組).收集患者一般資料、相關生化指標.使用FootScan系統收集足底壓力及步態相關參數.采用獨立樣本t檢驗、Mann-Whitney U檢驗、Spearman秩相關進行數據分析.結果 與DC組相比,DPN組左足第3、4跖骨的峰值壓力降低[(13.15±4.22)N/cm2 vs(11.96±3.94) N/cm2,P <0.05;(10.21±4.22) N/cm2 vs(9.14±3.66) N/cm2,P<0.05],右足第1、2、3跖骨峰值壓力降低[(6.02±2.79) N/cm2vs(5.04±2.87) N/cm2,P< 0.05;(9.95±2.69) N/cm2 vs(9.18±2.77) N/cm2,P <0.05;(10.90±3.23)N/cm2vs(9.93±3.09)N/cm2,P<0.05],其余區域峰值壓力、總應力、總接觸面積、總應力-時間積分、各區域壓力-時間積分的組間差異均無統計學意義(P>0.05).與DC組相比,DPN組右足的整足接觸階段[56.8%(50.22%~62.45%) vs 59.5%(54.25%~64.15%),P<0.05]延長,離地階段[31.25% (25.475% ~ 35.775%)vs 29%(24.95% ~33.65%),P<0.05]縮短,總時間[(858±12)ms vs(900±127)ms,P<0.05]延長,步行速度[(2.58±0.67) km/h vs(2.28±0.66) km/h,P<0.05]減慢.步行速度與多個區域的足底壓強呈正相關(P<0.05),支撐相中的整足接觸階段與峰值壓力呈負相關(P<0.05),離地階段與峰值壓力呈正相關(P<0.05).結論 糖尿病周圍神經病變患者足底壓力峰值、壓力-時間積分未見升高,步行速度減慢,整足接觸階段延長,離地階段縮短.對糖尿病患者足底壓力進行評價同時需要對步行速度及步態進行矯正,使用壓力-時間積分指標更能反映足底承受壓力情況.